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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I Am Confused On The FLC Ratio. Kappa To Lambda Is Within Range, But If I Calculate Lambda To Kappa It Is High. Any Guidance?

A MyMyelomaTeam Member asked a question 💭
Bristol, TN

Kappa FLC 30.3 Lambda FLC 85.7
K/L Ratio .35 L/K ratio 171.4

May 27
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A MyMyelomaTeam Member

I let my doctor figure out all that.

May 27
A MyMyelomaTeam Member

In light chain multiple myeloma, the serum free light chain (FLC) ratio is an important diagnostic criterion. Typically, the FLC ratio is calculated as kappa to lambda. A normal kappa to lambda ratio ranges from 0.26 to 1.65.

- Kappa to Lambda Ratio: If this ratio is within the normal range, it generally indicates no Show Full Answer

In light chain multiple myeloma, the serum free light chain (FLC) ratio is an important diagnostic criterion. Typically, the FLC ratio is calculated as kappa to lambda. A normal kappa to lambda ratio ranges from 0.26 to 1.65.

- Kappa to Lambda Ratio: If this ratio is within the normal range, it generally indicates no significant imbalance.
- Lambda to Kappa Ratio: If you calculate the inverse (lambda to kappa) and find it high, it suggests an imbalance favoring lambda chains.

For a specific diagnosis, a serum free light chain ratio of 100 or more (kappa to lambda or vice versa) is used to diagnose light chain multiple myeloma. If you have concerns about your results, it's best to discuss them with your healthcare provider for accurate interpretation and guidance.

May 27

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