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Can Anybody Tell Me If Daratumamab Is A Good Medication?

A MyMyelomaTeam Member asked a question 💭
Lancaster, CA
September 29
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A MyMyelomaTeam Member

Hi Christopher. I started Darzalex by IV infusion in October of 2017. It kept my numbers down until I could have a transplant in December of 2017. I took it with Pomalyst and dexamethasone. I started back on Darzalex 78 days post my transplant. I've been on Darzalex, with Pomalyst ever since. They let me drop the dex awhile back. I have high risk disease that was hard to knock down. So, I would have to say that Darzalex has been an excellent drug for me. I get it subcutaneous now, into my belly fat. Very convenient.

September 30
A MyMyelomaTeam Member

I’ve been getting fastpro dara for about 21 months since I relapsed (along with pomalyst ) and my mSpike is non detectable and labs are great. So I would say it does work. However , I must say that after the treatment , I do experience fatigue for 2 days and I am not my energetic self. Everyone is different, but that’s my experience. I hope that helps !

September 30
A MyMyelomaTeam Member

I was taking Dara for several years with Dexamethasone steroid and I was sick in bed for a week after my monthly treatment and just feeling crappy like really intense flu and really exhausted but other than that I felt good overall but the fatigue lessened but never went away completely. My Dr. tried cutting my infusion time from 3hrs. down to 2hrs. and I was really sick afterwards so I managed to convince her to go back to the 3hr. infusion and no problems after that. Sometimes you have to advocate for yourself because the Drs. aren’t always right. It did keep me in partial remission for a very long time so it works but the side effects can be rough sometimes.

September 30
A MyMyelomaTeam Member

Daratumumab (Darzalex) is a medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma, particularly in people who have tried other therapies or are ineligible for autologous stem cell transplant. It is often combined with other drugs such as Velcade, Pomalyst, or Revlimid, along with a Show Full Answer

Daratumumab (Darzalex) is a medication approved by the U.S. Food and Drug Administration (FDA) for treating multiple myeloma, particularly in people who have tried other therapies or are ineligible for autologous stem cell transplant. It is often combined with other drugs such as Velcade, Pomalyst, or Revlimid, along with a corticosteroid.

Key Points:
- Type: Monoclonal antibody, biologic.
- Mechanism: Attaches to myeloma cells, helping the immune system recognize and attack them.
- Administration: Intravenous infusion.
- Common Side Effects: Infusion site reactions, low blood cell counts, fatigue, dizziness, fever, chills, cough, cold or flu symptoms, nausea, vomiting, diarrhea, constipation, back pain, joint pain, muscle spasms, peripheral neuropathy, and swelling in the extremities.
- Serious Side Effects: Severe infusion site reactions and low blood cell counts.

For more details, you can visit the Darzalex website or the American Cancer Society's page on drug therapy for multiple myeloma.

September 29

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