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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Hi, Has Anyone Developed Osteonecrosis Of The Jaw From Xgeva Injections As I Have?

A MyMyelomaTeam Member asked a question 💭

In addition I also now have a chronic infection there as which they are finding difficult to treat because doing so as they normally would could definitely accelerate the Osteonecrosis. Four specialties have been involved - Dentist, Endodontist, Periodontist and Oral Surgeon. To date I've had four rounds of antibiotics which are only able suppress the infection for a short time but are unable to cure it. They are looking to extract a tooth and are in discussion with my Oncologist in that… read more

September 14
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A MyMyelomaTeam Member

So sorry this is happening to you. Primetime Gail had osteonecrosis. Some others have too.

September 14
A MyMyelomaTeam Member

Yes, osteonecrosis of the jaw (ONJ) has been reported in patients taking Xgeva (denosumab). The risk of developing ONJ increases with the dose and duration of treatment. It is more common after invasive dental procedures. Preventive antibiotics before dental procedures can lower the risk. If you have developed ONJ, it's Show Full Answer

Yes, osteonecrosis of the jaw (ONJ) has been reported in patients taking Xgeva (denosumab). The risk of developing ONJ increases with the dose and duration of treatment. It is more common after invasive dental procedures. Preventive antibiotics before dental procedures can lower the risk. If you have developed ONJ, it's important to discuss management and treatment options with your healthcare provider.

September 14

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