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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

What R Diagnostic Criteria ONC Should Include N A ‘complete Workup’ For Our Diagnosis, BMB %, Bone Scan Result, CRAB, Risk, IGM/iGA, Kappa?

A MyMyelomaTeam Member asked a question 💭
Tallahassee, FL

I need to know what all the ONC should provide for an upcoming diagnostic result and how it is provided via in a comprehensive report so I can send it out for a 2nd opinion and referral to a MMspecialists? Thank you

September 5
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A MyMyelomaTeam Member

To diagnose multiple myeloma, oncologists typically include the following diagnostic criteria in a complete workup:

1. Bone Marrow Biopsy (BMB)
- Detection of 10% or more malignant plasma cells in the bone marrow.
- Alternatively, detection of plasmacytoma in bones or soft tissues.

2. CRAB Criteria
- Calcium read more

To diagnose multiple myeloma, oncologists typically include the following diagnostic criteria in a complete workup:

1. Bone Marrow Biopsy (BMB)
- Detection of 10% or more malignant plasma cells in the bone marrow.
- Alternatively, detection of plasmacytoma in bones or soft tissues.

2. CRAB Criteria
- Calcium elevation (hypercalcemia)
- Renal failure (kidney impairment)
- Anemia (low red blood cell count)
- Bony lesions (bone damage)

3. Imaging Tests
- X-rays, MRI scans, CT scans, and PET scans to detect bone lesions or damage.

4. Serum Free Light Chain Assay
- A serum free light chain ratio of 100 or more, indicating light chain multiple myeloma.

5. Blood Work
- Serum albumin levels
- Beta macroglobulin levels
- Serum protein electrophoresis
- Urine electrophoresis

6. Cytogenetic Studies
- Analysis of bone marrow aspirate to examine genetic changes in myeloma cells.

7. Additional Biomarkers
- 60% or more malignant plasma cells in a bone marrow biopsy.
- Focal lesions of 5 millimeters or more.

These criteria help in diagnosing and staging multiple myeloma accurately.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Tests for Multiple Myeloma | MyMyelomaTeam
Multiple Myeloma – The Path to Diagnosis | MyMyelomaTeam
September 5

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