To diagnose multiple myeloma, oncologists typically include the following diagnostic criteria in a complete workup:

1. Bone Marrow Biopsy (BMB)
- Detection of 10% or more malignant plasma cells in the bone marrow.
- Alternatively, detection of plasmacytoma in bones or soft tissues.

2. CRAB Criteria
- Calcium Show Full Answer

To diagnose multiple myeloma, oncologists typically include the following diagnostic criteria in a complete workup:

1. Bone Marrow Biopsy (BMB)
- Detection of 10% or more malignant plasma cells in the bone marrow.
- Alternatively, detection of plasmacytoma in bones or soft tissues.

2. CRAB Criteria
- Calcium elevation (hypercalcemia)
- Renal failure (kidney impairment)
- Anemia (low red blood cell count)
- Bony lesions (bone damage)

3. Imaging Tests
- X-rays, MRI scans, CT scans, and PET scans to detect bone lesions or damage.

4. Serum Free Light Chain Assay
- A serum free light chain ratio of 100 or more, indicating light chain multiple myeloma.

5. Blood Work
- Serum albumin levels
- Beta macroglobulin levels
- Serum protein electrophoresis
- Urine electrophoresis

6. Cytogenetic Studies
- Analysis of bone marrow aspirate to examine genetic changes in myeloma cells.

7. Additional Biomarkers
- 60% or more malignant plasma cells in a bone marrow biopsy.
- Focal lesions of 5 millimeters or more.

These criteria help in diagnosing and staging multiple myeloma accurately.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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