Light chain multiple myeloma is diagnosed through a combination of tests and criteria:

Diagnostic Criteria:
1. General Myeloma Diagnosis:
- Detection of 10% or more malignant plasma cells in the bone marrow.
- Detection of plasmacytoma in bones or soft tissues.

2. Specific Criteria for Light Chain Multiple Myeloma Show Full Answer

Light chain multiple myeloma is diagnosed through a combination of tests and criteria:

Diagnostic Criteria:
1. General Myeloma Diagnosis:
- Detection of 10% or more malignant plasma cells in the bone marrow.
- Detection of plasmacytoma in bones or soft tissues.

2. Specific Criteria for Light Chain Multiple Myeloma:
- CRAB Criteria:
- Calcium elevation
- Renal failure
- Anemia
- Bony lesions
- New Criteria:
- 60% or more malignant plasma cells in a bone marrow biopsy.
- Focal lesions of 5 millimeters or more.
- Serum free light chain ratio of 100 or more.

Diagnostic Tests:
- Serum Free Light Chain Assay: Detects excess light chains in the blood.
- Urine Protein Electrophoresis Test (UPEP): Detects light chain myeloma caused by overproduction of lambda light chains (less common due to expense).

Treatment Regimes:
- General Treatments: Similar to other forms of myeloma.
- Complications: Light chains can cause kidney damage, affecting 40% of people with multiple myeloma.

Additional Information:
- Imaging: MRI, PET, and CT scans can show damage to bones or organs.
- Associated Conditions: Light chain multiple myeloma is often diagnosed along with light chain amyloidosis (AL amyloidosis).

For more detailed information, you can refer to the full guide on light chain multiple myeloma [here](https://www.mymyelomateam.com/resources/light-c...).

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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