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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I Posted Before But Not In Question Form. Is Beta 2 Microglobulin The Same As M Spike? Mine Is 3rd Highest After 4 Years 4.12.

A MyMyelomaTeam Member asked a question 💭
Cathedral City, CA

I am feeling good and had about 3 IGIG IV'S this year. What is going on.

August 4
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A MyMyelomaTeam Member

No, they are two different tests.

August 5
A MyMyelomaTeam Member

Beta-2 microglobulin and M spike are not the same.

- Beta-2 Microglobulin Test: This test looks for the presence of beta-2 microglobulin, a protein found on the surface of many cells, including myeloma cells. High levels can indicate a higher tumor burden and are used to assess the prognosis of multiple myeloma.

- M Show Full Answer

Beta-2 microglobulin and M spike are not the same.

- Beta-2 Microglobulin Test: This test looks for the presence of beta-2 microglobulin, a protein found on the surface of many cells, including myeloma cells. High levels can indicate a higher tumor burden and are used to assess the prognosis of multiple myeloma.

- M Spike: Also known as monoclonal protein or M protein, this is detected through tests like serum protein electrophoresis (SPEP). It measures the level of abnormal monoclonal antibodies produced by myeloma cells.

Your Beta-2 microglobulin level of 4.12 being the third highest after four years suggests a significant tumor burden, and it is important to discuss this with your healthcare provider for appropriate management.

August 4

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