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I’ve Yet Another Odd Question. Can You Have Say IgA Kappa Light Chain And IgG Lambda At The Same Time?

A MyMyelomaTeam Member asked a question 💭
Pottstown, PA
May 29
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A MyMyelomaTeam Member

A myeloma panel test all our immunoglobins. IgG, IgA, IgM they checked my IgE once. But my myeloma secretes a complete imunoglobulin, which means a heavy and a light chain which is IgG lambda. There are several types of myeloma.

May 30
A MyMyelomaTeam Member

Will just throw this out there: I’m greater than 70% positive plasma cells , IgG, lambda, loss of chromosome 8 plus 1q, plus more translocations rearrangements on 5,21,17,20 among others. prognosis unfavorable…advanced stage 3, 2-4 years survival estimate.. guess what. I’m still here and stable now with no chemo since last November. So as they say in galaxy quest .. never give up, never surrender!

May 30
A MyMyelomaTeam Member

Answer to first question
Yes, it's possible for plasma cells to produce both kappa and lambda light chains at the same time. This is called dual expression of kappa and lambda light chains and is a rare phenomenon. It can be a feature of plasma cell myeloma, which is a type of cancer where malignant plasma cells secrete monoclonal proteins (M-protein). M-protein is an abnormal immunoglobulin that can't fight infection properly.

May 30
A MyMyelomaTeam Member

Yes it is possible but I am not sure how much difference it makes. Good question for Oncologiists.
Good luck

June 1
A MyMyelomaTeam Member

Same here. Both K and L are above range but L is significantly higher

May 30

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