If you're seeking a second opinion for smoldering multiple myeloma (SMM), here are some key points to consider:

- Diagnosis: SMM is a precancerous condition that can lead to active multiple myeloma. It is often preceded by monoclonal gammopathy of unknown significance (MGUS)
- Monitoring: Regular follow-up visits and Show Full Answer

If you're seeking a second opinion for smoldering multiple myeloma (SMM), here are some key points to consider:

- Diagnosis: SMM is a precancerous condition that can lead to active multiple myeloma. It is often preceded by monoclonal gammopathy of unknown significance (MGUS).
- Monitoring: Regular follow-up visits and testing are crucial to monitor the condition's progress. This can help catch any progression to multiple myeloma early.
- Risk Factors: Certain factors increase the risk of SMM progressing to multiple myeloma, including:
- Plasma cells with specific gene changes
- High numbers of plasma cells in the bone marrow
- High levels of M protein
- M protein levels that increase over time
- M protein made from IgA heavy chain, rather than IgG
- Bone lesions visible on X-rays

- Treatment Options:
- Watchful Waiting: This approach involves regular monitoring without immediate treatment to avoid side effects.
- Bisphosphonates: Drugs like Aredia (pamidronate), Xgeva (denosumab), and Zometa (zoledronic acid) can strengthen bones and protect against damage.
- Early Treatment: For high-risk SMM, early treatment with drugs like Revlimid (lenalidomide) and low-dose Decadron (dexamethasone) may reduce the chances of developing multiple myeloma.

- Progression Rates:
- First 5 years after diagnosis: ~10% per year
- 5-10 years after diagnosis: ~3% per year
- 10+ years after diagnosis: ~1% per year

Consulting with a hematology and oncology specialist, such as Dr. Mark Levin, who has extensive experience in internal medicine, can provide valuable insights and a comprehensive evaluation of your condition.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Smoldering Multiple Myeloma: Your Guide | MyMyelomaTeam

Second Cancers and Myeloma: Understanding the Connection | MyMyelomaTeam