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NEW Drag - TECVALYI Teclisamab

A MyMyelomaTeam Member asked a question 💭
Philadelphia, PA

Hello all - now 4 year in to the journey of MM, I did it all . Bone Meroe , Car-t cell , and every drag possible. I just can’t tolerate those horrible drags more than few weeks , but somehow they kept me alive for almost 4 years - some worked some not - those side effects on steroids is hard !! in November 2022 the FDA approved a drag called teclisamab - it’s not chemical based - so is not chemo , it’s very complicated drag to start or to explain here , but I did go for it and I believe it… read more

February 9, 2023 (edited)
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A MyMyelomaTeam Member

It’s a drag that given by injection , that it attach to the WBC and together target the myloma cells . Follow that link for more .

https://www.tecvayli.com

February 9, 2023 (edited)
A MyMyelomaTeam Member

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August 12, 2023
A MyMyelomaTeam Member

Hi MGlive, I have watched a few webinars on Teclistamab. What side effects are you having? I hope they can be managed. It would be hard to get a shot every week. Sending hugs and prayers 💕

February 10, 2023 (edited)
A MyMyelomaTeam Member

Nope never heard of that. What is it exactly?

February 9, 2023 (edited)
A MyMyelomaTeam Member

It seems like you are referring to Tecvayli (teclistamab-cqyv). Here is some detailed information about Tecvayli based on the knowledge base:

Overview
- Tecvayli is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat relapsed or refractory multiple myeloma in adults
- It is intended for Show Full Answer

It seems like you are referring to Tecvayli (teclistamab-cqyv). Here is some detailed information about Tecvayli based on the knowledge base:

Overview
- Tecvayli is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat relapsed or refractory multiple myeloma in adults.
- It is intended for patients who have already tried at least four lines of therapy, including:
- A proteasome inhibitor
- An immunomodulatory agent
- An anti-CD38 monoclonal antibody

Mechanism of Action
- Tecvayli is a bispecific T-cell engager.
- The drug consists of a genetically engineered protein, or antibody, that targets:
- The B-cell maturation antigen (BCMA) on B cells, including myeloma cells
- The CD3 protein on T cells
- It works by prompting T cells to kill myeloma cells.

Administration
- Tecvayli is administered as a subcutaneous (under the skin) injection once a week after loading doses (initial large doses).
- It comes in the form of a single-dose vial.

Side Effects
- Common side effects include:
- Cytokine release syndrome (CRS), which can cause severe neurological symptoms such as hallucinations and tremors
- Fever
- Injection site reactions
- Fatigue
- Upper respiratory tract infections
- Nausea
- Headache
- Pneumonia
- Diarrhea
- Pain in the muscles, bones, or joints
- Rare but serious side effects include:
- Liver damage
- Severe or life-threatening infections
- Hypersensitivity reactions
- Fetal harm

For more details about this treatment, you can visit the official Tecvayli website provided by Janssen Biotech Inc.

August 2

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