I haven’t been on that combination, but I do know shortness of breath is a common side effect of many MM treatments. It can also be common due to the MM itself. The echo cardiogram should clear up any doubt. Good luck.

I was on rev, dex and xgeva. I was in remission after 3 months of chemo I had some shortness of breath and neuropathy in my feet and a little in my hands. The shortness of breath comes and goes and allergies could be part of that. The neuropathy is a little better and I hope it continues to improve. My oncologist says it could go away completely in time but that nerves heal slowly. So I am doing all I can to help that along... low carb diet, supplements and laser therapy which does seem to be helping. The numbness is still there but less pain and burning

I am on darzalex and pomalyst as well as dexamethazone and I experience SOB. It doesn’t occur all the time, but I attribute it to the medication.

Debby
I've had neuropathy in my feet since 2003. That's how I was diagnosed with MGUS (precursor to MM). I've just gotten used to it. Once you have it the symptoms can get better but it doesn't go away just like MM

Took Velcade and Dex during my chemo rounds VR-CAP. I did have weakness and shortness of breath. By 4 to 6 round I had to stop at least twice going up a set of stairs. Went away after I stopped the full chemo. My biggest complaint was the foot neuropathy. Still have numbness mainly in the toes and I stopoed velcade end of November 2018.