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Would Anyone Have Any Reaction To The Following Snippet Of My FISH Report?
"Signal patterns consistent with a MYC rearrangement and 13q14 deletion were observed in 4% and 6% of the cells scored, respectively. Thus, there was evidence to suggest low-level MYC rearrangement and 13q14 deletion, but no evidence of 1p32 deletion, 1q21 gain, gain of chromosome 5, 9, 15, or 21, IGH rearrangement, or TP53/17p13.1 deletion".
OK, AI, that was true 20 years or so ago. What about with today's treatments?
Kappa,
You don’t have most of the high risk factors. IGH or others. That’s really great!
Ha! Take that, you mean ol' AI:
"Monosomy 13/13q deletions (present in 50% of cases) have been associated with short survival in almost all large series of patients treated with both conventional and high-dose therapy. However, this adverse prognostic implication seems to stem primarily from its close association with other high-risk genetic features...
"Therefore, deletion of RB1 on 13q on its own is not a negative prognostic factor".
Citation:
Bergsagel, Leif & Mateos, Maria Victoria & Gutierrez, Norma & Rajkumar, S & Jimenez, Miguel. (2012). Improving overall survival and overcoming adverse prognosis in the treatment of cytogenetically high-risk multiple myeloma. Blood. 121. 10.1182/blood-(Phone number can only be seen by the question and answer creators).
The snippet from your FISH report indicates the following:
- MYC rearrangement: Observed in 4% of cells. This can be associated with a more aggressive form of myeloma.
- 13q14 deletion: Found in 6% of cells. This deletion is linked to a poorer prognosis in multiple myeloma.
However, there was no evidence of
- 1p32 Show Full Answer
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