No, the progression from smoldering multiple myeloma (SMM) to active multiple myeloma is not definite. Here are some key points:

- Risk of Progression
- First 5 Years: About 10% of people with SMM develop multiple myeloma each year.
- 5 to 10 Years: About 3% of people develop multiple myeloma each year.
- 10+ Show Full Answer

No, the progression from smoldering multiple myeloma (SMM) to active multiple myeloma is not definite. Here are some key points:

- Risk of Progression:
- First 5 Years: About 10% of people with SMM develop multiple myeloma each year.
- 5 to 10 Years: About 3% of people develop multiple myeloma each year.
- 10+ Years: About 1% of people develop multiple myeloma each year.

- Risk Factors:
- Plasma cells with certain gene changes.
- High numbers of plasma cells in the bone marrow.
- High levels of M protein.
- M protein levels that increase over time.
- M protein made from IgA heavy chain, rather than IgG.
- Bone lesions visible on X-rays.

Progression is influenced by these risk factors, but it is not guaranteed.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

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