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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Any High Risk Folks With Long Post Transplant Remission? What Is Your Treatment Plan?

A MyMyelomaTeam Member asked a question 💭
Valdez, AK

My transplant doctor suggested tandem transplant even before results from the first! there must be better options for high risk patients!

July 6
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A MyMyelomaTeam Member

Hey Alicia, I got one transplant in 2017. I'm high risk. Hard to treat myeloma with P53/17p deletion 11:14 translocation. I'm on Darzalex monthly and Pomalyst 2 MG 21 out of 28 days, since right after my transplant. My labs are good no m spike. Still mrd positive at 43 monoclonal cells per million. I do pretty well

July 7
A MyMyelomaTeam Member

so encouraging! thank you

July 6
A MyMyelomaTeam Member

My doctor prepped me for 2 transplants even before we did the first! That’s because of high risk and aggressive cancer.

But after 16 weeks of induction chemo and one transplant I went MRD negative! So he canceled the second one.

Now over a year out I’m fine on monthly maintenance!

July 6
A MyMyelomaTeam Member

For individuals with myeloma, achieving long post-transplant remission can vary based on several factors, including overall health and treatment history. Here are some key points:

- High-Risk Individuals: While bone marrow transplants are typically recommended for those under age 65, healthy and fit older individuals may Show Full Answer

For individuals with myeloma, achieving long post-transplant remission can vary based on several factors, including overall health and treatment history. Here are some key points:

- High-Risk Individuals: While bone marrow transplants are typically recommended for those under age 65, healthy and fit older individuals may also be considered candidates. Each case is reviewed individually for risk factors.

- Extended Remission: A study published in the journal Blood Advances showed that the five-year survival rate for people with myeloma who had bone marrow transplants increased from 35% to 63%, largely due to improved drug combinations used along with the transplant.

- Treatment Plan: If myeloma relapses, the treatment plan may include:
1. Restarting Original Therapy: If remission lasted at least six months to one year, reintroducing initial therapy can be successful around 50% of the time.
2. Another Bone Marrow Transplant: If the first transplant led to several years of remission, another autologous stem cell transplant (ASCT) might be recommended.
3. Proteasome Inhibitors: Drugs like carfilzomib (Kyprolis) and ixazomib (Ninlaro) may be used.
4. Immunotherapy: Options like chimeric antigen receptor T-cell therapy (CAR T-cell therapy) and bispecific T-cell engagers like teclistamab-cqyv (Tecvayli) are considered.

Your oncologist will tailor the treatment plan based on your overall health, previous treatments, and test results.

July 6
A MyMyelomaTeam Member

Consolidation? I guess I've been on it for seven years. I started Darzalex, Pomalyst and dex 78 days after transplant. The dexamethasone was dropped a few years ago. 🥰

July 8

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