Both Xgeva (Denosumab) and Zometa (Zoledronic acid) are used to strengthen bones in people with multiple myeloma. Here are some key points for each:

### Xgeva (Denosumab)
Pros
- Administration: Subcutaneous injection once every four weeks.
- Effectiveness: Prevents fractures and spinal cord compression by preventing bone Show Full Answer

Both Xgeva (Denosumab) and Zometa (Zoledronic acid) are used to strengthen bones in people with multiple myeloma. Here are some key points for each:

### Xgeva (Denosumab)
Pros:
- Administration: Subcutaneous injection once every four weeks.
- Effectiveness: Prevents fractures and spinal cord compression by preventing bone breakdown.
- Supplements: Often recommended to take calcium and vitamin D supplements.

Cons:
- Common Side Effects: Headache, fatigue, back pain, swelling in extremities, nausea, diarrhea, and anemia.
- Serious Side Effects: Low calcium levels, osteonecrosis of the jaw, atypical femoral fractures, hypersensitivity reactions, and fetal harm in pregnant women.
- Discontinuation Risk: Higher risk for vertebral fractures after stopping the treatment.

### Zometa (Zoledronic acid)
Pros:
- Administration: Intravenous (IV) infusion every three to four weeks.
- Effectiveness: Reduces bone lesions, improves pain, and lowers fracture risk by reducing osteoclast activity.

Cons:
- Common Side Effects: Nausea, fatigue, anemia, bone pain, constipation, fever, vomiting, and difficulty breathing.
- Serious Side Effects: Kidney toxicity, osteonecrosis of the jaw, atypical femoral fractures, fetal harm, hypersensitivity reactions, and severe bone, muscle, or joint pain.

Both treatments have their benefits and potential risks. It's important to discuss these options with your partner's healthcare provider to determine the best choice based on their specific health needs and medical history.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Xgeva (Denosumab) for Myeloma | MyMyelomaTeam

Zometa (Zoledronic acid) for Myeloma | MyMyelomaTeam