It really depends on which type of Myeloma you have.
I have light chain Myeloma so I don't really have an M-spike. I recently asked my dr why I don't have an M-Spike, since so many do. He said those with light chain don't the M protein spike. Light chains are basically deformed and slip through the kidneys instead of remaining in the blood.

You'll need to ask your doctor what it means for you.
J

I’m seeing a new doc Monday. I didn’t care for my first doc. I’m hoping I will get some clearer answers and he won’t be in such. Hurry. Hugs

I have Kappa Light Chain multiple Myeloma, and have never had a M Spike. Having no M spike is not necessarily an indication of remission. I’m in a national ClonoSEQ study. The purpose of the study is to run a comparison of obtaining ClonoSEQ results of Blood work vs Bone Marrow biopsy. The idea is to eventually do away with Bone Marrow biopsies. I get a Bone Marrow biopsy every 4-6 months, and have had around 12-15 in the last 4-5 years. My initial ClonoSEQ was 39,000 cancerous cells per million at the start of treatment. My ClonoSEQ is finally zero after almost 5 years. So I’m finally MRD negative.

Hi Robert - Congrats for being at zero. Sounds like it was a long road getting there.

That’s great that the two testing methods tracked so closely.

Seems that some Docs may be aware of the Trial’s progress - my Doc has been comfortable with testing me with blood samples from the onset. This being my first year off MM Meds, he’s doing quarterly clonoSEQ tests from blood work only.

I was very fortunate to be able to get DarzFasPro as part of my initial treatment. No way to know but C3 Curcumin may have helped me getting there and keeping me at MRD Negative.

Hope you have a very long lasting remission. Check out the video MRD2STOP. They’re feeling that people at Negative for two years are better-off getting off MM Meds. I sorta jump-the-gun and stopped after my first Negative Report.

All the Best

Hi Robert - For yourself, now that you know that you're MRD Negative, do you get your Reports from each clonoSEQ test, for both blood based and BMB based?

Would you be able to call their Customer Support and ask for your own reports - it would be very interesting to see how your own testing tracked.

Every quarter, I get my clonoSEQ test results and my Doc posts my results on their Portal as well.

I hope their testing proves to be valid from blood samples - that would be a fantastic leap forward for the care and management of MM.

My Doc and I are very comfortable tracking my progress from just blood samples. This year's PET/CT (about 3 months ago) was another indicator that All's Clear. I viewed the images from my current one vs the original from a year prior when I was at 80% bad plasma. My original PET/CT glowed with Uptake everywhere in my bones and this year, there was nothing more than a faint background noise and the radiologist report indicated No Uptake.

Again - Thanks for participating in this Study. Hopefully it will prove to be good news for all.