Dpaulovich, Hi. Everything that Donna and Wendym has posted is great information. Darzalex hopefully will get rid of the M-Spike altogether, but it can produce a therapeutic response and gives you a low M-Spike. It works on a protein that all Myeloma Cells have CD38. The goal being to kill all cancer cells which Darzalex, but good plasma cells can also be damaged making your Immune System vulnerable. Since Darzalex is a monoclonal antibody it can show M-Spikes in a low parameter but there is a new test - Hydrashift 2/4 Darazalex, that some institutions now use that recognizes the Darzalex response and does not show it to give a more accurate report. Hope this information helps, it is hard to understand the mode of action of these drugs. Maybe you should have this conversation with your doctor, he maybe able to explain it better and reassure you. Have a good day. Love, Marcia 🌼🌸🌻

Thanks @A MyMyelomaTeam Member for the information. Hope you are doing well and get some answers soon. 🙏

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A MyMyelo...

My doctor said the same. Told me not to worry about it since the Dara/Rev brought my Lamda light chain number way down

@A MyMyelomaTeam Member. I have Kappa Light chain Myeloma. I have never had an M spike until I started taking Daratumumab. Dara can appear in the serum of patients as IgG Kappa type M protein. The level that appears is very low. Mine has been around .14 Your doctor will have to order a special blood test to eliminate this result.

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A MyMyelo...

Emory has that, but Northside doesn't. The last SPEP I had at Northside showed an m spike in the Lambda region of 0.4. Which really freaked me out. Cause Darzalex is Kappa. And my myeloma is Lamda. Anyway Emory redid it and it was 0.0?? So we will see what it is in November. Glad you are up on this👍💕