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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

How do medical professional score MGUS risk of advancing to MM? Say based on M spike mg/dl or IGG concentration or FLK ratio or other?

A MyMyelomaTeam Member asked a question 💭
December 7, 2024
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A MyMyelomaTeam Member

For further expansion on the above answer you should look up the 20-2-20 test. Bone marrow cells above 20, lamba/kappa ratio above 20 and m protein above 2g/dl. If bone cells are over 10% you are then smoldering.

December 8, 2024
MyMyelomaTeam

Medical professionals assess the risk of MGUS progressing to multiple myeloma (MM) using factors like:

1. M protein (M spike) level: Higher levels increase risk
2. Immunoglobulin type: Non-IgG MGUS (e.g., IgA or IgM) has a higher risk.
3. Free light chain (FLC) ratio: An abnormal ratio suggests higher risk.
4. Bone marrow Show Full Answer

Medical professionals assess the risk of MGUS progressing to multiple myeloma (MM) using factors like:

1. M protein (M spike) level: Higher levels increase risk.
2. Immunoglobulin type: Non-IgG MGUS (e.g., IgA or IgM) has a higher risk.
3. Free light chain (FLC) ratio: An abnormal ratio suggests higher risk.
4. Bone marrow plasma cells: Higher percentages indicate greater risk.

These factors help classify MGUS as low, intermediate, or high risk. Regular monitoring is crucial.

December 7, 2024

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