I was in remission for about 15 months after my SCT. My MM is aggressive so my oncologist suggested a clinical trial. No more chemo but rather immunotherapy. Within 6 weeks I was back in remission and have been for 10 months. My labs are wonderful. I hope I never have to go back on chemo again. Good luck to you.

What Maintenance Meds are you on. DarzFasPro can create a False MSpike of up to 0.2. This will show in the SPEP, regardless of the type of MM.

Get the Lab test #123218 - IFE, Darz-Specific. Any mAb style Med and many other things like a Covid or Evusheld shot, as well as some Supplements and prescription meds can produce it.

Get a PET/CT to see if it can identify the source of the Activity - either Marrow based or an Active Bone Lesion.

Get a blood sample clonoSEQ MRD test to compare to the genetics of your original (Archived) BMB to see if you have any Marrow based MM Activity.

When my Bone Lesion became Active in April 2023, my clonoSEQ showed 6 cells per million, months before my Labs indicated the Activity. If your Marrow or a Bone Lesion is Active, the clonoSEQ blood sample MRD test will prove it, as well as a PET/CT should be able to find it.

Prove you're MM is Active rather than assuming anything. If Active, take appropriate Action.

Twice I was given excellent advise by my Interventional Radiologist that Radiation should be my Last Resort since Radiation turns Bone to Stone and MM Meds like Revlimid and Dex are Systemic, able to kill cancer throughout our body.

The world of MM Treatment is far too often a Sledge-Hammer when a Jeweler's Screw-Driver is all that's needed. Get Treatment when needed but, wisely can make a very big different on our Quality of Life.

Jamie, I have been in good control for 7 years. I have had about 3 times where I would have an m spike of 0.2. It wasn't from Darzalex. Since my facilities do the Darzalex specific test. Once, after I got a Covid vaccine, my m spike went up to 0.4. Anyway, I hope yours goes right back down.

I was in remission for 1 year and then also saw .2 mSpike. (That was a year after my SCT). I wanted a break from treatment and drugs , so I took a wait and see approach. Still had labs every 3 months. My mSpike went up gradually for 2 years with zero treatment. I had no symptoms. However , once my mSpike hit 2 +, I capitulated and knew it was time for my second line of treatment. I have been on pomalyst and Dara for almost 2 years and for 6 months I have had great labs and no detected mSpike . That was just my experience. My doctors wanted me to go on treatment probably six months prior to when I started , but I made the decision to wait.