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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Can Someone Explain To Me What This Fish Report Means :cells Positive For Igh T(11:14), CKS1b(1q) Addition(lowlevel,+1extrasignal),p53 Delit

A MyMyelomaTeam Member asked a question 💭
Oakland, NJ
September 14
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A MyMyelomaTeam Member

Unfortunately, a lot of them. Look at the top left and you will see Resources. Click on that and you will find different articles about this cancer. You should be able to find a list of high risk features.
Paula🌹

September 15
A MyMyelomaTeam Member

Which one is bad deletion or addiction

September 15
A MyMyelomaTeam Member

Getta,
FISH report look for translocations, additions and deletions, but the only ones you need to focus on are the ones that were detected. I have IgA Kappa, t(14;16) with 16q deletion, Monosomy 13 and +5.

September 15
A MyMyelomaTeam Member

What about t(4;14),t(14:16),t(14;20),cdkn2c(1p)deletion, abnormality chromosome 3 9,11

September 14
A MyMyelomaTeam Member

The FISH (fluorescence in situ hybridization) report you mentioned includes several genetic abnormalities that are relevant to multiple myeloma:

- IGH t(11;14): This indicates a translocation between chromosome 11 and chromosome 14 involving the immunoglobulin heavy chain (IGH) gene. This translocation is common in read more

The FISH (fluorescence in situ hybridization) report you mentioned includes several genetic abnormalities that are relevant to multiple myeloma:

- IGH t(11;14): This indicates a translocation between chromosome 11 and chromosome 14 involving the immunoglobulin heavy chain (IGH) gene. This translocation is common in multiple myeloma and can influence the disease's behavior and response to treatment.

- CKS1B (1q) addition (low level, +1 extra signal): This refers to an additional copy of part of chromosome 1q. The presence of extra copies of 1q21 (where the CKS1B gene is located) is associated with a poorer prognosis in multiple myeloma.

- p53 deletion: This indicates a deletion of the p53 gene, which is located on chromosome 17p. The loss of p53 is associated with more aggressive disease and a worse prognosis.

These genetic abnormalities can help doctors determine the risk level and guide treatment decisions for multiple myeloma.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Multiple Myeloma Prognosis: Survival Rates, Light Chain, and More Factors | MyMyelomaTeam
Creating a Positive Outlook While Living With Myeloma | MyMyelomaTeam
September 14

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