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Can Someone Explain To Me What This Fish Report Means :cells Positive For Igh T(11:14), CKS1b(1q) Addition(lowlevel,+1extrasignal),p53 Delit

A MyMyelomaTeam Member asked a question 💭
Oakland, NJ
September 14
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A MyMyelomaTeam Member

Unfortunately, a lot of them. Look at the top left and you will see Resources. Click on that and you will find different articles about this cancer. You should be able to find a list of high risk features.
Paula🌹

September 15
A MyMyelomaTeam Member

The FISH (fluorescence in situ hybridization) report you mentioned includes several genetic abnormalities that are relevant to multiple myeloma:

- IGH t(11;14): This indicates a translocation between chromosome 11 and chromosome 14 involving the immunoglobulin heavy chain (IGH) gene. This translocation is common in Show Full Answer

The FISH (fluorescence in situ hybridization) report you mentioned includes several genetic abnormalities that are relevant to multiple myeloma:

- IGH t(11;14): This indicates a translocation between chromosome 11 and chromosome 14 involving the immunoglobulin heavy chain (IGH) gene. This translocation is common in multiple myeloma and can influence the disease's behavior and response to treatment.

- CKS1B (1q) addition (low level, +1 extra signal): This refers to an additional copy of part of chromosome 1q. The presence of extra copies of 1q21 (where the CKS1B gene is located) is associated with a poorer prognosis in multiple myeloma.

- p53 deletion: This indicates a deletion of the p53 gene, which is located on chromosome 17p. The loss of p53 is associated with more aggressive disease and a worse prognosis.

These genetic abnormalities can help doctors determine the risk level and guide treatment decisions for multiple myeloma.

September 14
A MyMyelomaTeam Member

Thank you Paula , I will rest Larry2 story 🙏💕

October 28
A MyMyelomaTeam Member

Getta,
That is great news! Responding well is key! Read @A MyMyelomaTeam Member story. It’s important not to take the maintenance too long. Maybe take a break and start again? Read his story and you will understand.
Paula🌹

October 28
A MyMyelomaTeam Member

Hi Paula Thanks for your reply, yes I go to a MM specialist at memorial Sloan Kettering in NJ , I did well with my treatment and SCT. , I am waiting now for the first maintenance treatment , I hope it goes smooth

October 28

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