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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I Am Interested As To What A De-escalation Plan Looked Like For Someone Who Refused Stem Cell Transplant After Remission For 3 Months Now.

A MyMyelomaTeam Member asked a question 💭
Port Ludlow, WA

Started chemo treatment in Jun 2023, some oral meds were reduced I.e. Revlamid was reduced to 15 mg.

May 28
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A MyMyelomaTeam Member

Thank you. Just to clarify - I am still on chemo infusions every two weeks plus Velcade every 2 weeks and Revlamid for 21 days and then off for 7 days.

May 28
A MyMyelomaTeam Member

If someone refuses a stem cell transplant after being in remission for three months, the de-escalation plan would typically involve alternative treatments to manage their multiple myeloma. Here are some potential steps:

1. Restarting Original Therapy: If the initial therapy led to remission, it might be restarted. This Show Full Answer

If someone refuses a stem cell transplant after being in remission for three months, the de-escalation plan would typically involve alternative treatments to manage their multiple myeloma. Here are some potential steps:

1. Restarting Original Therapy: If the initial therapy led to remission, it might be restarted. This approach is often successful if remission lasted at least six months to one year.

2. Maintenance Therapy: Adjusting maintenance therapy, such as adding dexamethasone combined with lenalidomide (Revlimid), to help maintain remission.

3. Proteasome Inhibitors: Using drugs like bortezomib (Velcade) or carfilzomib (Kyprolis) to target and destroy myeloma cells.

4. Immunomodulatory Drugs: Medications like thalidomide, lenalidomide, or pomalidomide to boost the immune system's ability to fight myeloma.

5. Monoclonal Antibodies: Treatments like daratumumab (Darzalex) or elotuzumab (Empliciti) that target specific proteins on myeloma cells.

6. Clinical Trials: Exploring new treatments through clinical trials that might offer additional options.

7. Supportive Care: Managing symptoms and side effects to improve quality of life, including pain management, nutritional support, and psychological counseling.

Each plan is tailored to the individual's specific condition and needs, and it's essential to discuss all options with a healthcare provider.

May 28

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I Am Interested In Thoughts (pro And Con) About Stem Cell Transplant. It Seems Like A Very Extreme Procedure With Little Overall Benefit.

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We're Facing A Stem Cell Transplant. Any Suggestions For How To Prepare And What To Expect? Thanks!

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