I was in the same situation so my oncologist suggested CAR-T Cell Therapy. I had it done in May of last year. At that time I was given 6 to 9 months. I am now in remission for 7 months. I highly recommend it.

Here's the Case Study that shows continued use of Darz & DarzFasPro results in them losing effectiveness due to the MM expressing less CD38.

Then based on a 6 month and 12 month break from these mAb Meds, they can regain most of their effectiveness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10...

CD38 antibody re-treatment in daratumumab-refractory multiple myeloma after time on other therapies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598487/

Mark, there other options for you. There were two new drugs just recently approved last August. They’ll come up with something for you! 🙏

Give Dara a 6 month break - it's very likely that it will regain its ability to work.
I've read a Case Study that documented this. I'll post a Link to that one once I find it again.

Dara also kills off your Natural Killer Cells - the link below is to the graph is from a Case Study that shows Dara kills Natural Killer Cells (extremely important for our defense). After 6 months, they regained most of their original levels.

https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/t...

Here's the article that includes the above graph.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC57...

Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728278/

Thanks. I'm anxious to review this with my oncologist whose usual we'll informed.