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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Pomalyst

A MyMyelomaTeam Member asked a question 💭
Long Beach, CA

First of all good afternoon everybody! Have anybody been on this drug Pomalyst for any period of time and did you have any side effects like hives or rashes or what?

January 16, 2023
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A MyMyelomaTeam Member

I've been on Pomalyst for several months, along with dex and darzalex infusions. No reactions so far (knock wood)!

March 20, 2023
A MyMyelomaTeam Member

In addition, now that I’ve been on pomalyst for a bit , cough , phlegm and fatigue. But good news is my mSpike is now normal and so is my Igg. However white blood cells have dropped. Been through one cycle. We shall see what happens down the road. Hoping the trajectory stays the same and side effects become minimal. That’s it for now ! Hope everyone is doing well

April 4, 2023
A MyMyelomaTeam Member

My husband has been on Polymast, (along with Kyprolis and Dexamethasone) for close to 4 months now, hasn’t had the itching you describe so far. It seems to have helped his MM numbers, as no M spike has been detected in last 2 light chain bloodwork, other numbers better also. They do give him Benadryl with his Kyprolis.

March 19, 2023
A MyMyelomaTeam Member

I've been on Pomalyst since around March 2017. No rash. My skin does at times, have a burning sensation. My scalp gets itchy. I get awful fatigue and constipation. Mostly I deal with it okay. I believe rash is common. They usually give antihistamines and steroid creams. I hope it goes away. 💕

January 16, 2023
A MyMyelomaTeam Member

Pomalyst (pomalidomide) is a prescription medication approved by the FDA to treat multiple myeloma that has progressed after being treated with other therapies. Here are some key details:

- Combination Therapy: Often combined with a corticosteroid, typically dexamethasone
- Mechanism: It is an immunomodulator, meaning it Show Full Answer

Pomalyst (pomalidomide) is a prescription medication approved by the FDA to treat multiple myeloma that has progressed after being treated with other therapies. Here are some key details:

- Combination Therapy: Often combined with a corticosteroid, typically dexamethasone.
- Mechanism: It is an immunomodulator, meaning it modulates the immune system. It may prevent the growth of new blood vessels that supply tumors.
- Administration: Taken orally on days 1 through 21 in a 28-day cycle.
- Form: Comes in the form of a capsule.

Common Side Effects:
- Fatigue
- Low blood count
- Constipation
- Nausea
- Diarrhea
- Infections of the upper respiratory tract
- Back pain
- Fever

Serious Side Effects:
- Liver failure
- Blood toxicity
- Tumor lysis syndrome
- Hypersensitivity
- Severe skin reactions

For more details, you can visit the Pomalyst page on MyMyelomaTeam: [Pomalyst (Pomalidomide) for Myeloma](https://www.mymyelomateam.com/treatments/pomalyst).

July 9
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