Norpramin (Desipramine) for Myeloma

Overview
Norpramin is a prescription medication approved by the U.S. Food and Drug Administration (FDA) for the treatment of depression. Norpramin may be mildly effective at managing neuropathic pain, a common side effect of myeloma treatment. There is some evidence that Norpramin may assist in the mobilization of stem cells in people with myeloma after an autologous stem cell transplant. Norpramin is also known by its drug name, desipramine.

Norpramin is a tricyclic antidepressant. It is believed that Norpramin works by changing the balance of neurotransmitters in the brain.

How do I take it?
Norpramin is generally taken one or more times a day.

Norpramin comes in tablet form.

Side effects
The FDA-approved label for Norpramin lists common side effects including headache, drowsiness, lack of coordination, weakness, dry mouth, nausea, constipation, diarrhea, increased appetite, weight gain, sexual dysfunction, ringing in the ears, and blurred vision.

Rare but serious side effects listed for Norpramin include suicidal thoughts or behavior and the worsening of depressive symptoms.

For more details about this treatment, visit:

Norpramin — RxList
http://www.rxlist.com/norpramin-drug.htm

Pain, Pain, Go Away: Antidepressants and Pain Management — National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27...

Peripheral Neuropathy — Myeloma UK
https://www.myeloma.org.uk/wp-content/uploads/2...

Managing Treatment-Related Peripheral Neuropathy in Patients With Multiple Myeloma — OncologyNurseAdvisor
https://www.oncologynurseadvisor.com/home/cance...

Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G-CSF in multiple myeloma: A pilot study — American Journal of Hematology
https://pubmed.ncbi.nlm.nih.gov/28675459/