John,
If you read the article, there is a heading- “Gene or Chromosome Changes”. It gives a list of changes, deletions or translocations. I have IgA Kappa which is a higher risk marker, but I also have t(14;16) with 16q deletion, Monosomy 13 and +5. Except for the +5, all the other markers I have mean a higher risk of progression and poor prognosis. The one I don’t have is amplification of chromosome 1, which carry’s a higher risk. I believe t(4;14) carry’s a higher risk than t(14;16). Is this what you were asking? Please feel free to ask Moore questions. It’s a lot to understand. After my diagnosis of MGUS I started reading as many articles I could find. If you are going to do any research, understand that anything older than 2 years old may be an outdated article, since MM research has taken off and is changing fast.
Paula🌹

An excellent question John747. So many kinds and types my head is spinning. Non-secretory, solitary plasmacytoma, extra medullary plasmacytoma, light chain, MGUS, SMM, and so on. I read somewhere that there is IgA, IgD, IgE, IgG, IgM.

If you’re interested in overall survival time there are so many factors. Age wise under 50 is best then 50-64 and the worst is diagnosis 65 and up. Then you must factor in genetics; additions, deletions, amplifications and one other one. Then I just read where if you go into remission quickly after treatment that greatly helps prognosis. I hope that’s me.

But to answer your question we need a 3-D matrix showing time on the Y axis, the various kinds and types on the X axis and these other factors on the Z axis.

Mind boggling.

All this data is out there and we don’t need a Cray Supercomputer to analyze this. You remember the Cray from 40 years ago.

I’m still working on my data!
IgG Kappa Light Chain
Additions, deletions, etc
Spread to shoulder, hip, spine, liver
Diagnosed age 71
High risk
Very Aggressive

It doesn’t sound good.

Spinning.

I wish some analytical consortium would plug in my specific data and pump out the best prediction for my life span based on those who had what I have.

I know. I didn’t answer your question but suffice it to say the worst multiple myeloma are the ones that morph into MDS and leukemia. Then you got real problems.

🤔🥺