The progression estimates from smoldering multiple myeloma (SMM) to multiple myeloma are as follows:

- First 5 years after diagnosis: About 10% of people develop multiple myeloma each year
- 5 to 10 years after diagnosis: About 3% of people develop multiple myeloma each year.
- 10 years or more after diagnosis: About 1% Show Full Answer

The progression estimates from smoldering multiple myeloma (SMM) to multiple myeloma are as follows:

- First 5 years after diagnosis: About 10% of people develop multiple myeloma each year.
- 5 to 10 years after diagnosis: About 3% of people develop multiple myeloma each year.
- 10 years or more after diagnosis: About 1% of people develop multiple myeloma each year.

Certain risk factors can increase the chances of progression, including:
- Plasma cells with certain gene changes
- High numbers of plasma cells in the bone marrow
- High levels of M protein
- M protein levels that increase over time
- M protein made from IgA heavy chain, rather than IgG
- Bone lesions visible on X-rays

For personal experiences, you can connect with others on MyMyelomaTeam, a social network for people with multiple myeloma and their loved ones.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Smoldering Multiple Myeloma: Your Guide | MyMyelomaTeam

Stage 1 Multiple Myeloma: What To Expect | MyMyelomaTeam