I'm sorry to hear about your situation. A sudden increase in M protein, or M spike, can indeed indicate a relapse of multiple myeloma. According to my knowledge base, a relapse is often diagnosed based on:

- Increased plasma cells in the bone marrow
- Higher levels of monoclonal antibodies or M protein
- Newly formed or Show Full Answer

I'm sorry to hear about your situation. A sudden increase in M protein, or M spike, can indeed indicate a relapse of multiple myeloma. According to my knowledge base, a relapse is often diagnosed based on:

- Increased plasma cells in the bone marrow
- Higher levels of monoclonal antibodies or M protein
- Newly formed or growing plasmacytomas or bone lesions

It's important to discuss these changes with your healthcare team to determine the next steps.

 This AI-generated response comes from MyMyelomaTeam and other selected sources. It is not a substitute for medical advice. Always ask your doctor about specific health concerns.

Understanding Serum Protein Electrophoresis (SPEP) for Multiple Myeloma | MyMyelomaTeam

7 Symptoms of Multiple Myeloma Relapse To Look Out For | MyMyelomaTeam